Death from a morphine infusion during a sickle cell crisis.
case_report · Level V
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- Record sourced from PubMed, PMID 8345436.
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Abstract
A 15-year-old boy died during a vaso-occlusive sickle cell crisis after having received a prolonged infusion of morphine. Even in therapeutic doses, narcotics may cause significant respiratory acidosis and hypoxemia, enhancing polymerization of hemoglobin SS and thereby promoting sickling and vaso-occlusion. When narcotics are used during a sickle cell crisis, the best method is pharmacokinetically based patient-controlled analgesia.
Medical subject headings
- Anemia, Sickle Cell
- Death, Sudden, Cardiac
- Morphine
- Pain
- Respiratory Insufficiency