Characterization of a new human bladder cancer cell line, UCRU-BL-28.
basic_science · Level V
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Abstract
A new human bladder cancer cell line, UCRU-BL-28 has been established and characterized from a relapsed, cisplatin resistant, grade II, stage T4 tumor. This line is tumorigenic in nude mice and reflects the pathology of the original tumor. The morphology, the expression of tumor-associated antigens and EGF receptors, and the ability to grow both in an anchorage independent manner and in the absence of serum is explored. The BL-28 line has 71-74XXY chromosomes, with del 5q, der(9) and i(19q). Further studies on the molecular basis of bladder cancer, chemosensitivity to cisplatin, growth factor production and tissue invasion are under way.
Medical subject headings
- Carcinoma, Transitional Cell
- Tumor Cells, Cultured
- Urinary Bladder Neoplasms