Vigabatrin and depression.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 8350115.
- Also identified by PMC identifier 1015155.
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Abstract
Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.
Medical subject headings
- Aminocaproates
- Anticonvulsants
- Depressive Disorder