Identification of a structural glycoprotein of an RNA virus as a ribonuclease.
basic_science · Level V
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Abstract
One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.
Medical subject headings
- Classical Swine Fever Virus
- Ribonucleases
- Viral Structural Proteins