Inhibition of non-enzymatic lipid peroxidation by 'Essentiale' a drug enriched in phosphatidylcholine in ethanol-induced liver injury.
basic_science · Level V
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Abstract
The effect of 'Essentiale'--a drug, now clinically listed in European countries in the treatment of liver diseases was examined in ethanol-induced liver injury in rats (free access to a 20% ethanol solution for 3 months). The antioxidant enzymes, SOD (superoxide dismutase), CAT (catalase), GSH-R (glutathione reductase), non-protein and total SH groups as well as TBA-rs contents were investigated. Following treatment, we found beneficial effects in SOD and CAT activities. The above enzyme activities were restored after a 3-month drug administration. Furthermore, 'Essentiale' treatment normalized TBA-rs levels in the liver. These effects have been briefly discussed.
Medical subject headings
- Antioxidants
- Lipid Peroxidation
- Liver Cirrhosis, Alcoholic
- Liver Cirrhosis, Experimental
- Phosphatidylcholines