The results of treatment in 100 patients with limited-stage small cell lung cancer.

Abstract

In an attempt to improve treatment results of small cell lung cancer (SCLC), combined induction chemotherapy and thoracic and prophylactic brain radiation therapy were administered. From December 1980 to December 1987, 112 patients with limited-stage SCLC were treated with combination induction chemotherapy and thoracic or prophylactic brain radiation therapy; 100 were evaluable. The complete response rate was 40%, and complete and partial responses totaled 94%, with a 5-year survival rate of 23%. There was no difference in remission and survival rates between three-drug and four-drug induction chemotherapeutic regimens. Six chemotherapeutic courses produced longer survival than less therapy. Although the occurrence of brain metastases was no different with or without prophylactic brain radiation therapy, the 3-year survival after this procedure was improved. Treatment of limited-stage SCLC with induction chemotherapy and thoracic and prophylactic brain radiation therapy produced improved remission and survival rates.