Crystal structure of globular domain of histone H5 and its implications for nucleosome binding.
basic_science · Level V
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Abstract
The structure of GH5, the globular domain of the linker histone H5, has been solved to 2.5 A resolution by multiwavelength anomalous diffraction on crystals of the selenomethionyl protein. The structure shows a striking similarity to the DNA-binding domain of the catabolite gene activator protein CAP, thereby providing a possible model for the binding of GH5 to DNA.
Medical subject headings
- Histones
- Nucleosomes
- Protein Structure, Secondary