Effect of caval-portal shunt on ovarian tissue in rats: I. Histological observation.

Abstract

Forty-three female Sprague Dawley rats were divided into five groups, with groups 1-4 subjected to end-to-side caval-portal shunt (CPS). In addition to CPS, group 1 (n = 13), group 2 (n = 10), and group 3 (n = 7) rats had undergone removal of the right ovary and one-half of the left ovary, the left ovary, and one-half of the left ovary, respectively. Group 4 (n = 6) rats were not subjected to ovariectomy. Group 5 (n = 7) animals were not subjected to CPS but underwent left ovarian hemiresection. The ovarian volume of the hemiresected ovaries increased to 393.00 +/- 4.83 mm3 and 126.00 +/- 44.3 mm3 from 18.40 +/- 0.54 mm3 and 18.40 +/- 0.59 mm in groups 1 and 3, respectively, at the end of three postoperative months. The nonresected ovaries enlarged to 339.98 +/- 5.09 mm3 and 226.3 +/- 46.2 mm3 from 36.79 +/- 1.09 mm3 in groups 2 and 3, respectively. When no ovaries were resected, the CPS animals in group 4 showed an increment of ovarian volume of 1.75-2.2 times as much as the preoperative ones. In the animals that had undergone simple hemiovariectomy (group 5), the contralateral ovaries showed a significant increase in volume (40.2 +/- 8.3 mm3 to 243.1 +/- 114.8 mm3) at 3 months. The hemiresected ovarian volume increased from 27.1 +/- 5.5 mm3 to 44.1 +/- 11.8 mm3.(ABSTRACT TRUNCATED AT 250 WORDS)