Prevention of carcinogenicity of anticancer drugs by metallothionein induction.
basic_science · Level V
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Abstract
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.
Medical subject headings
- Anticarcinogenic Agents
- Bismuth
- Carcinogens
- Chlorides
- Cisplatin
- Lung
- Lung Neoplasms
- Melphalan
- Metallothionein
- Nitrates
- Zinc Compounds