Brain myosin-V is a two-headed unconventional myosin with motor activity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8402892.
- Also identified by DOI 10.1016/S0092-8674(05)80080-7.
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Abstract
Chicken myosin-V is a member of a recently recognized class of myosins distinct from both the myosins-I and the myosins-II. We report here the purification, electron microscopic visualization, and motor properties of a protein of this class. Myosin-V molecules consist of two heads attached to an approximately 30 nm stalk that ends in a globular region of unknown function. Myosin-V binds to and decorates F-actin, has actin-activated magnesium-ATPase activity, and is a barbed-end-directed motor capable of moving actin filaments at rates of up to 400 nm/s. Myosin-V does not form filaments. Each myosin-V heavy chain is associated with approximately four calmodulin light chains as well as two less abundant proteins of 23 and 17 kd.
Medical subject headings
- Brain
- Calmodulin-Binding Proteins
- Myosin Type V
- Nerve Tissue Proteins