A clinico-pathological study of adult histiocytosis X involving the brain.

Hasegawa, K; Mitomi, T; Kowa, H; Motoori, T; Yagisita, S · J Neurol Neurosurg Psychiatry · 1993

case_report · Level V

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Abstract

Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.

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