Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood.
case_report · Level V
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Abstract
A 14-year-old girl with chronic hepatitis B had seroconversion from hepatitis B e antigen to antibody and achieved biochemical remission after 2 years. The disease reactivated 9 years later when a precore mutant had become the prevalent hepatitis B virus strain in serum. These results suggest that selection of a precore mutant might induce reactivation during adult life of chronic hepatitis B acquired in childhood, thus worsening the prognosis.
Medical subject headings
- Hepatitis B
- Hepatitis B virus
- Hepatitis, Chronic