New roles for G-protein beta gamma-dimers in transmembrane signalling.
basic_science · Level V
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Abstract
When a membrane-bound receptor acts on a G protein, the GTP-binding or G alpha subunit dissociates from the G beta gamma dimer. Until recently, the G alpha subunit alone was thought to act on the enzymes and ion channels controlled by these proteins. Newer evidence indicates that the G beta gamma dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.
Medical subject headings
- GTP-Binding Proteins
- Signal Transduction