Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8413585.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappa B site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappa B enhancer binding proteins and basal transcription factors which leads to enhanced transcription.
Medical subject headings
- DNA-Binding Proteins
- NF-kappa B
- Proto-Oncogene Proteins
- Transcription Factors
- Transcription, Genetic