Parallel genome analysis by two-dimensional DNA typing.
basic_science · Level V
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- Record sourced from PubMed, PMID 8413593.
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Abstract
By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.
Medical subject headings
- DNA
- Electrophoresis, Gel, Two-Dimensional