Combined thrombolytic therapy for prosthetic mitral valve thrombosis.
case_report · Level V
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- Record sourced from PubMed, PMID 8417667.
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Abstract
Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.
Medical subject headings
- Heart Valve Prosthesis
- Mitral Valve
- Mitral Valve Insufficiency
- Postoperative Complications
- Puerperal Disorders
- Rheumatic Heart Disease
- Thrombolytic Therapy
- Thrombosis
- Tissue Plasminogen Activator
- Urokinase-Type Plasminogen Activator