Extremity transplantation: a review of its current state of development.

Nolan, L M; Bowen, V · J Hand Surg Am · 1993

review · Level V

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Abstract

The discovery of a powerful immunosuppressive, cyclosporin A, together with the development of a microsurgical free tissue transfer technique, has brought extremity transplantation closer to being a realistic possibility. In this review the authors describe the history of laboratory research into extremity transplantation before immunosuppression, with early immunosuppressive agents, with cyclosporin A, and with FK-506, one of a new generation of immunosuppressives.

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