Parental age, genetic mutation, and cerebral palsy.
case_control · Level III
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- Record sourced from PubMed, PMID 8423607.
- Also identified by PMC identifier 1016233.
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Abstract
Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
Medical subject headings
- Cerebral Palsy
- Maternal Age
- Mutation
- Paternal Age