Increase of Parkinson disability after fluoxetine medication.

Steur, E N · Neurology · 1993

case_series · Level IV

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Abstract

Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic capacity of fluoxetine in Parkinson's disease patients must be considered.

Medical subject headings