Propofol decreases random and chemotactic stimulated locomotion of human neutrophils in vitro.
basic_science · Level V
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Abstract
We have studied the influence of clinical concentrations of propofol (2,6-diisopropyl phenol), emulsified propofol (Diprivan) and the emulsifier of propofol (Intralipid 10%) on random and chemotactic locomotion of human polymorphonuclear leucocytes in an agarose assay. Random locomotion was decreased (P < 0.001) to a similar extent by the three drugs. Concentrations of propofol 2.5 micrograms ml-1 and greater, and of Diprivan 3.33 micrograms ml-1 and greater, also reduced chemotaxis (P < 0.05) against both zymosan-activated human serum (C5a) and N-formyl-methionyl-leucylphenylalanine (FMLP), used as chemoattractants. Intralipid reduced chemotaxis towards C5a but not towards FMLP. We conclude that propofol in clinically relevant concentrations may adversely affect leucocyte locomotion in vitro.
Medical subject headings
- Chemotaxis, Leukocyte
- Propofol