Immune-mediated thrombocytopenia secondary to suramin.
case_report · Level V
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- Record sourced from PubMed, PMID 8431868.
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Abstract
The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma. On withdrawal of suramin, the acute and severe thrombocytopenia did not respond initially to plasmapheresis; subsequently, it resolved promptly and dramatically during the administration of intravenous gamma globulin, also coinciding with a decline in suramin blood levels. Results of immunologic and coagulation studies are reported and clinical implications discussed.
Medical subject headings
- Suramin
- Thrombocytopenia