Frequent presence of anti-GQ1b antibody in Fisher's syndrome.
case_series · Level IV
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- Record sourced from PubMed, PMID 8437711.
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Abstract
We used the enzyme-linked immunosorbent assay to investigate autoantibodies against the gangliosides GM1, GD1a, GD1b, GT1b, GD2, and GQ1b in sera from 16 patients with Fisher's syndrome. We found high anti-GQ1b antibody titers, mainly those of the IgG class, in the sera of 13 of these patients. The titers decreased with the clinical course of the illness. Moreover, anti-GQ1b antibody-positive patients had more severe ataxia of cerebellar type than the antibody-negative patients.
Medical subject headings
- Autoantibodies
- Gangliosides
- Polyradiculoneuropathy