HLA-DP positive T cells in patients with polymyositis/dermatomyositis.
case_series · Level IV
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- Record sourced from PubMed, PMID 8441171.
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Abstract
The examination of HLA-DP+ T cells in 21 patients with polymyositis/dermatomyositis revealed marked increases [28.5% (SD 16.6%)], compared with the HLA-DQ+ and DR+ T cells. The HLA-DP molecule was expressed on both CD4+ and CD8+ T cells. The majority of HLA-DP+ CD8+ cells were cytotoxic T cells. There was no significant correlation between the proportion of HLA-DP+ T cells and the level of myogenic enzyme, although a decrease in HLA-DP+ T cells after therapy was accompanied by a decrease in myogenic enzymes. However, the proportion of HLA-DP+ CD8+ cells was significantly higher in those patients with active pneumonitis.
Medical subject headings
- Dermatomyositis
- HLA-DP Antigens
- Polymyositis
- T-Lymphocytes