HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis.
case_report · Level V
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Abstract
Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.
Medical subject headings
- Cholangitis, Sclerosing
- Colitis, Ulcerative
- Diabetes Mellitus, Type 1
- HLA-DQ Antigens
- HLA-DR3 Antigen