Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
other · Level V
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- Record sourced from PubMed, PMID 8460642.
- Also identified by PMC identifier 1682078.
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Abstract
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
Medical subject headings
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Ovarian Neoplasms
- Proto-Oncogenes