Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease.
case_report · Level V
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Abstract
Three children with homozygous sickle cell disease, 22 months and 8 and 10 years of age, had clinical and hematologic manifestations of aplastic and splenic sequestration crisis simultaneously. They had an acute drop in hemoglobin level (16, 20, and 45 gm/L), reticulocytopenia (0.1%, 0.6%, and 0.3%), and sudden splenic enlargement. Evidence of recent parvovirus infection was demonstrated.
Medical subject headings
- Anemia, Aplastic
- Anemia, Sickle Cell
- Erythema Infectiosum
- Parvovirus B19, Human
- Splenomegaly