Topical sucralfate in the treatment of vaginal ulceration.

Abstract

Non-neoplastic vaginal ulceration is at times recalcitrant to traditional methods of treatment. Sucralfate, a basic aluminum salt of sucrose octasulfate, binds preferentially to ulcerated areas and promotes healing, an effect that does not appear to be acid-dependent. Three cases of vaginal ulceration were treated with vaginal douches of sucralfate 10% suspension twice daily. One of the cases was due to laser ablation for intraepithelial neoplasia, one was of uncertain etiology, and one was caused by pessary use. After failure of the initial therapeutic regimens, sucralfate treatment was successful in all three cases and was well tolerated without side effects. Sucralfate vaginal douches should be considered for the treatment of non-neoplastic vaginal ulcerations, particularly when other therapy has failed.