Hypothesis: cartilage catabolic cofactors in human arthritis.
Level V
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Abstract
Cartilage degradation in rheumatoid arthritis (RA) and osteoarthritis (OA) is commonly thought to be mediated by interleukin 1 (IL-1) and tumor necrosis factor (TNF). However, recent new evidence suggests that IL-1 and TNF on their own do not mediate all the cartilage changes seen in RA and OA. We propose that cartilage degradation is mediated by a complex network of cytokines, including IL-1, TNF and at least one cofactor present in synovial fluid.
Medical subject headings
- Arthritis, Rheumatoid
- Cartilage, Articular
- Interleukin-1
- Osteoarthritis
- Tumor Necrosis Factor-alpha