Lymphocytes from the site of disease suggest adenovirus is one cause of persistent or recurrent inflammatory arthritis.
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Abstract
The assessment of synovial lymphocyte reactivity to adenovirus antigen stimulation was undertaken in patients with persistent or recurrent inflammatory arthritis. The 3H-thymidine uptake procedure was employed, incorporating multiple microbiological antigens. Five patients were found with repeated maximal responses to adenovirus antigen; in one of these adenovirus nucleotide sequences were present in a synovial biopsy specimen. It is concluded that adenovirus may be one cause of persistent or recurrent inflammatory arthritis.
Medical subject headings
- Adenovirus Infections, Human
- Arthritis, Infectious
- Lymphocytes