Decreased bone mineral density in HLA-B27 positive members of a family with osteogenesis imperfecta.
case_series · Level IV
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- Record sourced from PubMed, PMID 8474070.
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Abstract
We describe a family in which several members had osteogenesis imperfecta (OI) and/or were positive for HLA-B27. The proband, who had ankylosing spondylitis and OI, had severe osteoporosis with fractures continuing to occur in the late teens. Bone mineral density measurements in 5 family members and the proband, revealed more severe osteoporosis in those with positive HLA-B27.
Medical subject headings
- Bone Density
- HLA-B27 Antigen
- Osteogenesis Imperfecta
- Spondylitis, Ankylosing