Penetration of fusidic acid into human brain tissue and cerebrospinal fluid.
rct · Level II
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Abstract
Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.
Medical subject headings
- Blood-Brain Barrier
- Brain
- Brain Diseases
- Fusidic Acid
- Premedication
- Surgical Wound Infection