Ketoconazole administration in hypercortisolemic depression.
case_series · Level IV
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- Record sourced from PubMed, PMID 8480829.
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Abstract
Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.
Medical subject headings
- Depressive Disorder
- Hydrocortisone
- Ketoconazole