C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.
basic_science · Level V
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Abstract
Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Helminth Proteins
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Vulva
- ras Proteins