Controlled release of polypeptides from polyanhydrides.
basic_science · Level V
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- Record sourced from PubMed, PMID 8483931.
- Also identified by PMC identifier 46469.
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Abstract
The effects of both polymer hydrophobicity and addition of stabilizers on the release and integrity of polymer-encapsulated proteins were studied. By using very hydrophobic poly[1,3-bis(p-carboxyhydroxy)hexane anhydride] with sucrose as an excipient, both recombinant bovine somatotropin and zinc insulin were released intact over 3 weeks. The released proteins appeared to maintain their integrity as judged by acidic reverse-phase HPLC, size-exclusion HPLC, radioimmunoassay, and conformation-sensitive immunoassays. Our results also suggest how polymer hydrophobicity can be used to enhance protein stability.
Medical subject headings
- Decanoic Acids
- Growth Hormone
- Insulin
- Polyesters