Yersinia associated arthritis in SHR rats: effect of the microbial status of the host.
basic_science · Level V
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- Record sourced from PubMed, PMID 8484677.
- Also identified by PMC identifier 1005022.
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Abstract
Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.
Medical subject headings
- Arthritis, Reactive
- Rats, Inbred SHR
- Yersinia Infections