Immunogenicity of Haemophilus influenzae type b conjugate vaccine in children with congenital asplenia.
case_series · Level IV
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- Record sourced from PubMed, PMID 8486956.
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Abstract
The immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugate vaccines in congenitally asplenic children is unknown. The short-term immunogenicity of the H. influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine was therefore assessed in 10 children with congenital asplenia by measuring antipolyribosyl-ribitol phosphate antibody titers. An excellent antibody response was seen in 9 children (mean geometric titer in responders after immunization 44.7 micrograms/mL; range, 2.59-402). The remaining child responded to a booster dose. Further studies are required to assess whether H. influenzae type b conjugate vaccines are immunogenic in infancy in the presence of congenital asplenia.
Medical subject headings
- Bacterial Vaccines
- Diphtheria Toxoid
- Haemophilus Vaccines
- Haemophilus influenzae
- Spleen