T cell activation and cytokine release in streptococcal toxic shock-like syndrome.
case_report · Level V
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Abstract
A 5-year-old girl with streptococcal toxic shock-like syndrome during varicella infection had high levels of tumor necrosis factor alpha and interleukin-6 but no interleukin-1 or interleukin-2 in the serum. Intravenous administration of gamma-globulin coincided with clinical improvement and with reduction of the levels of tumor necrosis factor alpha and interleukin-6. The data suggest that streptococcal pyrogenic exotoxins trigger synthesis of tumor necrosis factor alpha and interleukin-6 in vivo; intravenously administered gamma-globulin may down-regulate the cytokine response.
Medical subject headings
- Cytokines
- Shock, Septic
- Streptococcal Infections
- Streptococcus pyogenes
- T-Lymphocytes