Systemic histiocytosis presenting as multiple sclerosis.

Smith, M E; Katz, D A; Harris, J O; Frank, J A; Kufta, C V; McFarlin, D E · Ann Neurol · 1993

case_report · Level V

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Abstract

A patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.

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