Increased interleukin 6, but reduced interleukin 1, in delayed pressure urticaria.

Lawlor, F; Bird, C; Camp, R D; Barlow, R; Barr, R M; Kobza-Black, A; Judge, M R; Greaves, M W · Br J Dermatol · 1993

cross_sectional · Level IV

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Abstract

Interleukin 1 (IL-1) and interleukin 6 (IL-6) were measured by bioassays in suction-blister exudates from lesional skin, from skin immediately following a pressure challenge, and from control skin (not subjected to pressure) of patients with delayed pressure urticaria. IL-6 activity in lesional exudates was significantly higher than in exudates from the other two sites. IL-1 activity in lesional exudates was not significantly higher than in the control exudates, but significantly less IL-1 activity was found immediately after pressure challenge than from the control site.

Medical subject headings