Crystal structure of cyclin-dependent kinase 2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8510751.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
Medical subject headings
- CDC2-CDC28 Kinases
- Cyclin-Dependent Kinases
- Protein Kinases
- Protein Serine-Threonine Kinases