Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8511588.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.
Medical subject headings
- B-Lymphocytes
- CD8 Antigens
- Interleukins
- Lymphocyte Activation
- T-Lymphocyte Subsets