Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.
basic_science · Level V
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- Record sourced from PubMed, PMID 8524811.
- Also identified by PMC identifier 40449.
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Abstract
GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.
Medical subject headings
- DNA-Binding Proteins
- Genetic Variation
- Peptide Chain Initiation, Translational
- Transcription Factors