Production of interleukin-5 and the suppressive effect of cyclosporin A in childhood severe atopic dermatitis.
case_report · Level V
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Abstract
A child with severe atopic dermatitis had marked improvement with oral cyclosporin A (CyA) therapy. The function of activated T lymphocytes and serum interleukin-5 concentrations were reduced. The expression and production of interleukin-5 were high, but were suppressed during CyA therapy and by CyA in vitro. Oral CyA therapy may be useful for severe atopic dermatitis.
Medical subject headings
- Cyclosporine
- Dermatitis, Atopic
- Interleukin-5