Structure of the sodium channel pore revealed by serial cysteine mutagenesis.
basic_science · Level V
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- Record sourced from PubMed, PMID 8552626.
- Also identified by PMC identifier 40226.
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Abstract
The pores of voltage-gated cation channels are formed by four intramembrane segments that impart selectivity and conductance. Remarkably little is known about the higher order structure of these critical pore-lining or P segments. Serial cysteine mutagenesis reveals a pattern of side-chain accessibility that contradicts currently favored structural models based on alpha-helices or beta-strands. Like the active sites of many enzymes of known structure, the sodium channel pore consists of irregular loop regions.
Medical subject headings
- Ion Channel Gating
- Sodium Channels