Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
rct · Level II
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Abstract
We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.
Medical subject headings
- Amantadine
- Cocaine
- Dopamine Agonists
- Heroin Dependence
- Methadone
- Substance Withdrawal Syndrome
- Substance-Related Disorders