Channel behavior in a gamma-aminobutyrate transporter.
basic_science · Level V
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- Record sourced from PubMed, PMID 8570623.
- Also identified by PMC identifier 40121.
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Abstract
Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions in an occluded pore.
Medical subject headings
- Carrier Proteins
- Ion Channel Gating
- Ion Channels
- Membrane Proteins
- Membrane Transport Proteins
- Organic Anion Transporters
- gamma-Aminobutyric Acid