Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.
basic_science · Level V
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- Record sourced from PubMed, PMID 8577714.
- Also identified by PMC identifier 40030.
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Abstract
The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand. This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.
Medical subject headings
- DNA Replication
- HSP90 Heat-Shock Proteins
- Hepatitis B virus
- RNA, Viral
- RNA-Directed DNA Polymerase