Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 8577725.
- Also identified by PMC identifier 40041.
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Abstract
We have used alanine scanning to analyze protein-protein interactions by human TATA-element binding protein (TBP) within the transcription preinitiation complex. The results indicate that TBP interacts with RNA polymerase II and general transcription factors IIA, IIB, and IIF within the functional transcription preinitiation complex and define the determinants of TBP for each of these interactions. The results permit construction of a model for the structure of the preinitiation complex.
Medical subject headings
- DNA-Binding Proteins
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational
- Promoter Regions, Genetic
- Protein Conformation
- RNA Polymerase II
- Transcription Factors
- Transcription Factors, TFII