Evidence for a mechanistic association between nonbacterial prostatitis and levels of urate and creatinine in expressed prostatic secretion.

Abstract

Chronic prostatitis is a common disease of the late teenage years, which affects patients for many years. In the majority of cases etiology is unknown but in some cases prostatitis is clearly caused by microorganisms that result from overuse of antibiotic drugs. We attempt to gain further knowledge about the etiology of the disease. We studied 56 patients with nonbacterial prostatitis in regard to whether urine reflux into the prostatic ducts was responsible for increased concentrations of creatinine, urate and white blood cells in expressed prostatic secretion. The patients were interviewed using a standard questionnaire. A relationship was demonstrated between pain estimated in accordance with a scoring scale, and expressed prostatic secretion contents of white blood cells, urate and creatinine. These results provide further support of the role of reflux into the prostatic ducts as an underlying mechanism initiating a chemical inflammatory reaction. Urate appears to be the chemical agent eliciting this inflammatory response.