Carbamazepine-induced hepatitis in a patient with cervical myelopathy.
case_report · Level V
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Abstract
Carbamazepine is a drug commonly used in the treatment of neuropathic pain. It is an iminostilbene derivative that is extensively metabolized by the liver. We describe a 66-year-old man with dysesthetic pain from cervical myelopathy who developed cholestatic hepatitis, skin rash, and eosinophilia after carbamazepine was administered for 5 weeks (total dose of 18.9gm). Withdrawal of carbamazepine led to complete resolution of both clinical and biochemical abnormalities within 3 weeks. Clinicians should be alert to this rare complication because it can be confused clinically with biliary tract sepsis and viral hepatitis.
Medical subject headings
- Carbamazepine
- Chemical and Drug Induced Liver Injury
- Drug Eruptions
- Eosinophilia
- Lipoxygenase Inhibitors
- Neuralgia
Anatomy
- cervical spine